PNC-27 10 MG
PNC‑27 is a synthetic peptide sequence designed to bind selectively to HDM‑2 , a protein commonly overexpressed on the surface of certain abnormal or rapidly…
Mechanism of Action
See published literature and COA for batch-specific analytical data. Research use only — not for human or veterinary administration.
Research Applications
- In vitro laboratory research
- Receptor and pathway assays
- Comparative peptide studies
Specifications
| appearance | See COA for lot-specific appearance and identity confirmation |
Reconstitution (Laboratory)
Reconstitute with bacteriostatic water under sterile laboratory conditions unless otherwise specified for your protocol.
Storage & Handling
Lyophilized: 2–8 °C long-term. Reconstituted: refrigerate at 2–8 °C. Protect from light.
Quality Assurance
Every lot undergoes independent third-party HPLC purity analysis, mass spectrometry identity confirmation, and endotoxin testing (<0.5 EU/mg). Certificate of Analysis (COA) is stored against the SKU lot number and available through your research account portal.
Sources & References
- 1.Sarafraz-Yazdi E, et al. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010. · PubMed →
- 2.Thadi A, et al. Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. Anticancer Res. 2020. · PubMed →
- 3.Sarafraz-Yazdi E, et al. PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines. 2022. · PubMed →