Fox-04 (10mg)
FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the FOXO4-p53 interaction in senescent cells, investigated as a senolytic agent in aging and cellular senescence research.
Mechanism of Action
The D-retro-inverso modification confers protease resistance. The peptide competitively interferes with FOXO4-p53 binding, selectively inducing apoptosis in senescent cells while sparing proliferating cells in preclinical models.
Research Applications
- Cellular senescence and senolytic assays
- FOXO4-p53 interaction studies
- Aging and tissue rejuvenation research models
Specifications
| sequence | D-retro-inverso FOXO4-p53 interfering peptide |
| molecular Weight | ~5350 Da |
| appearance | White lyophilized powder |
Reconstitution (Laboratory)
Reconstitute with bacteriostatic water. Handle as a sensitive research peptide.
Storage & Handling
Lyophilized: −20 °C recommended for long-term. Reconstituted: refrigerate; use promptly.
Quality Assurance
Every lot undergoes independent third-party HPLC purity analysis, mass spectrometry identity confirmation, and endotoxin testing (<0.5 EU/mg). Certificate of Analysis (COA) is stored against the SKU lot number and available through your research account portal.